- Title
- Chemical renal medullectomy prevents frusemide-induced inhibition of sympathetic vasoconstriction in the in situ blood perfused rat mesentery
- Creator
- Gerkens, John F.; Armsworth, Stuart J.; Bhagwandeen, Surridhine B.; Smith, Anthony J.
- Relation
- Journal of Hypertension Vol. 5, Issue 3, p. 273-275
- Publisher
- Lippincott Williams & Wilkins
- Resource Type
- journal article
- Date
- 1987
- Description
- The mesentery of anaesthetized rats was perfused in situ at a constant rate, via the cannulated superior mesenteric artery, with blood drawn from a cannulated carotid artery. Increases in perfusion pressure were produced by peri-arterial electrical stimulation of the mesenteric sympathetic nerves at 3, 6 and 10 Hz before and after the intravenous administration of frusemide 5 mg/kg. Loss of solutes and volume as a result of frusemide-induced diuresis was prevented by a urinary bladder-venous shunt. In control animals the vasoconstrictor responses to mesenteric nerve stimulation were significantly reduced after frusemide administration. However, in animals pretreated 4 weeks previously with bromethylamine (BEA) 200 mg/kg i.p., frusemide had no effect on vasoconstrictor responses. Chemical papillectomy with BEA has been shown by others to prevent the antihypertensive effects attributed to the non-prostanoid lipids produced by the interstitial cells of the renal medulla. Our data suggest that the vasoconstrictor-inhibiting effect of frusemide may be mediated by the release of renomedullary lipids.
- Subject
- frusemide; chemical medullectomy; bromoethylamine; vasoconstriction; hypertension
- Identifier
- http://hdl.handle.net/1959.13/1397167
- Identifier
- uon:34204
- Identifier
- ISSN:0263-6352
- Language
- eng
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